A Robust Static Headspace GC-FID Method to Detect and Quantify Formaldehyde Impurity in Pharmaceutical Excipients
نویسندگان
چکیده
منابع مشابه
Detection and Quantification of Formaldehyde by Derivatization with Pentafluorobenzylhydroxyl Amine in Pharmaceutical Excipients by Static Headspace GC/MS
Although considered pharmacologically inert, pharmaceutical excipients have been shown to interact with active drug substances to affect the safety and efficacy of drug products.1 Therefore, there is an increasing awareness of the necessity to understanding interactions between excipients and the active pharmaceutical ingredient (API) in finished dosage forms. One of the areas of major concern ...
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The determination of residual solvents in pharmaceuticals is one of the most important gas chromatography (GC) applications in quality assurance/quality control (QA/QC) in the pharmaceutical industry. Sample introduction is normally done using static headspace (SHS). In routine QC, GC with flame ionization detection (FID) is preferred, while mass spectrometry (MS) can be used for screening and ...
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AbstractThe oldest method for the managing of the illness is the use of medicinal plants. The use of herbal products as the first choice in self-treatment of minor conditions continues to expand rapidly across Iran. This makes the safety of herbal products an important public health issue.Pesticides are used widely in agriculture to increase the production by controlling the harmful insects and...
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A simple and rapid method for determination of 17 -estradiol in pharmaceutical preparation was developed and validated using gas chromatography with flame ionization detection (GC-FID). The solutions of standard and the sample were prepared in methanol. GC separation was performed in about 7.7 min using a 30 m x 0.32 mm I.D. (film thickness 0.25 μm) HP-5 capilary column. Nitrogen was used as c...
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ژورنال
عنوان ژورنال: Journal of Analytical Methods in Chemistry
سال: 2018
ISSN: 2090-8865,2090-8873
DOI: 10.1155/2018/4526396